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Where the Bench Meets the Bedside


Investigator Manual


II.            Training 

The CRC is the focal point for training young physician-scientists in the process of clinical investigation. This process begins through a program offered to house staff. There are three components to this program: dedicated mentors, a research project, and didactic sessions. The program begins in the intern year when a faculty mentor is chosen from a list of dedicated mentors from BIDMC or from within the Harvard Medical School system. The mentor will work with the house officer in developing the timelines and providing guidance for the research component of the course. Lastly, there is a didactic lecture component. The lecture topics range from how to best use PowerPoint in presentations to study design, the IRB process, grant writing, and publishing. For further information on this training opportunity, contact Steven D. Freedman, MD, PhD either via e-mail or at (617) 667-4269.

Researchers may participate in the Clinical Investigator Training Program (CITP), which was created in 1993. The program represents a unique merger between the fields of healthcare, academia, and industry; and is supported by the Beth Israel Deaconess Medical Center, the Harvard-MIT Division of Health Sciences and Technology, and by a grant from Pfizer, Inc. and Merck & Co.

The goal of the fellowship is the training of physicians from a variety of clinical disciplines in the techniques and processes utilized in patient orientated research. The program is based on a specific curriculum that allows trainees to develop direct experience in the performance of clinical investigation and, at the same time, through didactic course work, provides them with strong foundation in the computational and statistical sciences, biomedical ethics, principals of clinical pharmacology, in vitro and in vivo measurement techniques, and many aspects of the drug development process. The program is funded by Pfizer Inc., and Merck & Co. which also contribute faculty to the didactic curriculum.

Upon completion of the two years of training, the fellows have developed a strong foundation in patient-oriented research. They are able to apply contemporary research tools to clinically relevant areas of investigation, and they are competitive for careers in patient-orientated research in academic medicine, industry, and regulatory affairs.

Fellows have the option to pursue a Master of Medical Sciences Degree from Harvard Medical School in conjunction with the Clinical Investigator Training Program. The degree is awarded at the end of the two-year period, upon successful completion of the program requirements. For further information about the Clinical Investigator Training Program contact Linda Bard (617) 667-4816.

CRC investigators may also participate in the Scholars in Clinical Science Program, a two-year post-graduate training program in clinical investigation. Funded by a Clinical Research Curriculum Award from the National Institutes of Health, the Scholars in Clinical Science Program consists of formal didactic coursework, a longitudinal seminar series, and a mentored clinical research project. Similar to the Clinical Investigator Training Program, the Scholars in Clinical Science Program was established to address the critical need for formal training opportunities in clinical research, which is vital to the advancement of scientific knowledge and the development of improved treatments for human disease. The goal of the SCSP is to provide superior, coordinated didactic and practical training for individuals interested in careers in translational investigation (human physiology, pathophysiology, and genetics), human pharmacology, and clinical trials. The program prepares trainees to be effective leaders of complex research groups, academic departments, academic medical centers, or industrial or managed care groups.

The CRC also encourages the development of independent clinical investigation through participation in the Mentored Patient-oriented Research Career Development Award (K23) program, a competitive NIH program for investigators who seek further training in clinical investigation. The purpose of the K23 award is to support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research. This mechanism provides support for three to five years of supervised study and research for clinically trained professionals who have the potential to develop into productive, clinical investigators focusing on patient-oriented research. For more information about NIH-funded training opportunities, please contact Michelle Beck (617) 667-4269.

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The Harvard-Thorndike CRC is funded by Grant M01 RR01032 from the NCRR, NIH
Please send general questions about the CRC to the Administrative Manager.
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