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Kaposi's sarcoma (KS) is a characteristic manifestation of HIV
infection occurring primarily in gay and bisexual men. It often
presents when the CD4 count is between 500 and 200. This tumor
originates in cells which normally form capillaries and lymphatic
channels, and is now known to be caused by human herpesvirus,
type 8. Skin lesions can be macular, nodular, or plaque-like,
are usually nontender and nonpruritic, and do not blanch with
pressure. KS may spread viscerally in advanced HIV disease. Management
depends upon the location and extent of lesions and may include
local treatment, radiation therapy, or systemic chemotherapy.
Improvement has also been noted in patients receiving combination
antiretroviral therapy. |
