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Aphthous ulcerations or "canker sores"
are recurrent, painful, clean-based oral lesions of unknown etiology.
This condition is generally self-limited but may persist in
HIV-infected patients. It generally responds to topical steroid therapy,
but some refractory cases have required thalidomide. Mouth ulcers in HIV
disease have a broad differential diagnosis, including herpes
simplex infection, syphilis, neoplasia, and drug toxicity. |
