| Toxoplasma
gondii, a
protozoan associated with asymptomatic infection in many normal
adults, can reactivate in patients with advanced HIV disease to
produce central nervous system mass lesions. Symptomatology ranges
from subtle personality changes to major motor and sensory deficits,
seizures, and coma. Diagnosis is made by CT scan with contrast
or by MRI scan, which typically shows multiple enhancing brainstem
lesions. Treatment consists of sulfadiazine and pyrimethamine. |
